NEUROSCIENCE RESEARCH AND DRUG DISCOVERY IN 
CHANNELOPATHIES
CHANNELOPATHIESThe research objectives will:
* Optimise
photolabile caged amino acid neurotransmitters for photolysis with the two
photon effect and develop new caged ligands for use in neuroscience.
* Develop new fast pulsed laser sources
* Develop techniques of wavefront modulation in microscopy to optimise photolysis and imaging deep in the brain in vivo
* Apply flash photolysis of caged neuroactive amino acids in high throughput screening at glutamate and GABA receptors.
* Develop new fast pulsed laser sources
* Develop techniques of wavefront modulation in microscopy to optimise photolysis and imaging deep in the brain in vivo
* Apply flash photolysis of caged neuroactive amino acids in high throughput screening at glutamate and GABA receptors.
* Develop
somatic cell therapy for neuroscience.
Flexible
and stable optical parametric oscillator based laser system for
coherent anti-Stokes Raman scattering microscopy.
Zhang W, Parsons M, McConnell G.
Microsc Res Tech.
2009 Nov 25. [Epub ahead of print]PMID:
19941296 [PubMed - as supplied by publisher]Related
articles
Temperature
dependence of N-methyl-d-aspartate receptor channels and
N-methyl-d-aspartate receptor excitatory postsynaptic currents.
Korinek M, Sedlacek M, Cais O, Dittert I, Vyklicky L Jr.
Neuroscience. 2009 Oct 31.
[Epub ahead of print]PMID:
19883737 [PubMed - as supplied by publisher]Related
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Vangeleyn M,
Griffin PF, Riis E, Arnold AS. Opt Express. 2009 Aug 3;17(16):13601-8.
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Trigo FF, Papageorgiou G, Corrie JE, Ogden D.
J Neurosci Methods. 2009 Jul 30;181(2):159-69. Epub 2009 May 5.
Essential role for the putative S6 inner pore region in the activation gating of the human TRPA1 channel.
Benedikt J, Samad A, Ettrich R, Teisinger J, Vlachova V.
Biochim Biophys Acta. 2009 Jul;1793(7):1279-88. Epub 2009 May 5.
The other recent Publications on PubMed